{"event":{"id":"evt-hist-20251015-c2sscale","dedupe_key":"ai_biology_model_release_and_in_vitro_research_report:2025-10-15:google-and-yale-announce-c2s-scale-27b-and-an-in-vitro-validated-cancer-immunology-hypothesis","event_type":"ai_biology_model_release_and_in_vitro_research_report","title":"Google and Yale announce C2S-Scale 27B and an in-vitro-validated cancer immunology hypothesis","summary":"On 15 October 2025 Google announced Cell2Sentence-Scale 27B built on Gemma, available to researchers, and reported in-vitro human cell-model validation of the predicted combination of silmitasertib and low-dose interferon increasing antigen presentation. The experiment was reported in cells, not in human clinical trials; no cancer treatment efficacy or regulatory approval is established. The cited preprint originated earlier, and the October event is the public announcement and model release.","occurred_at":"2025-10-15T00:00:00.000Z","published_at":"2025-10-15T00:00:00.000Z","observed_at":"2026-10-17T14:10:00.000Z","reconstructed_at":"2026-10-17T14:10:00.000Z","ingest_type":"historical_backfill","locations":null,"status":"verified","confidence":0.94,"metadata":{"external_postcutoff_id":"2025-10-15-c2s-scale-gemma-cancer-hypothesis","evidence_only":1,"new_relation_onset":0,"date_precision":"day","milestone":"primary_source_public_announcement_and_model_release","attribution":"first_party_lab_report","research_maturity":"in_vitro_only","source_access_caveat":"bioRxiv preprint 10.1101/2025.04.14.648850 returned access denied on direct fetch; primary October Google announcement directly read.","canonical_overlap_caveat":"No exact match in bounded title/source URL lookup or relevant 21-layer readbacks; search is not proven exhaustive."},"created_at":"2026-10-17T14:25:14.367Z","updated_at":"2026-10-17T14:25:14.367Z"},"artifacts":[{"id":"art-hist-20251015-c2sscale","dedupe_key":"53cbc65bef9fe7fefca655b1e97a0583201004576a0c9791216b35f08b031c9b","canonical_url":"https://blog.google/innovation-and-ai/products/google-gemma-ai-cancer-therapy-discovery/","evidence_locator":"","artifact_type":"dated_primary_research_announcement","title":"How a Gemma model helped discover a new potential cancer therapy pathway","summary":"","creator_entities":[],"released_at":"2025-10-15T00:00:00.000Z","content_hash":null,"metadata":[],"created_at":"2026-10-17T14:25:14.366Z","updated_at":"2026-10-17T14:25:14.366Z","relation":"documented_by"}],"signals":[]}